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Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder.

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Title: Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder.
Authors: West RM; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Bizga Nicolescu RC; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Brear P; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Wagstaff J; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Blaszczyk BK; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Deingruber T; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Sanders MG; Oncology Targeted Discovery, Oncology R&D, The Discovery Centre, AstraZeneca, Cambridge CB2 0AA, U.K., Pérez-Areales FJ; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Spring DR; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Hyvönen M; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Source: Journal of medicinal chemistry [J Med Chem] 2026 May 28; Vol. 69 (10), pp. 12099-12121. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22West+RM%22">West RM</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.<br /><searchLink fieldCode="AU" term="%22Bizga+Nicolescu+RC%22">Bizga Nicolescu RC</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.<br /><searchLink fieldCode="AU" term="%22Brear+P%22">Brear P</searchLink>; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.<br /><searchLink fieldCode="AU" term="%22Wagstaff+J%22">Wagstaff J</searchLink>; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.<br /><searchLink fieldCode="AU" term="%22Blaszczyk+BK%22">Blaszczyk BK</searchLink>; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.<br /><searchLink fieldCode="AU" term="%22Deingruber+T%22">Deingruber T</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.<br /><searchLink fieldCode="AU" term="%22Sanders+MG%22">Sanders MG</searchLink>; Oncology Targeted Discovery, Oncology R&D, The Discovery Centre, AstraZeneca, Cambridge CB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Pérez-Areales+FJ%22">Pérez-Areales FJ</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.<br /><searchLink fieldCode="AU" term="%22Spring+DR%22">Spring DR</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.<br /><searchLink fieldCode="AU" term="%22Hyvönen+M%22">Hyvönen M</searchLink>; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
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              Text: 2026 May 28
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