Improving Efficiency in Geographic Atrophy Clinical Trials Using Run-In Phases or Single-Arm Designs.

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Title: Improving Efficiency in Geographic Atrophy Clinical Trials Using Run-In Phases or Single-Arm Designs.
Authors: Hou J; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland., von der Emde L; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.; Department of Ophthalmology, University of Bonn, Bonn, Germany., Mukherjee S; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland., Vance E; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland., de Silva T; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland., Shen LL; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina.; Department of Ophthalmology, University of California, San Francisco., Keenan TDL; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Source: JAMA ophthalmology [JAMA Ophthalmol] 2026 Jun 01; Vol. 144 (6), pp. 529-535.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589539 Publication Model: Print Cited Medium: Internet ISSN: 2168-6173 (Electronic) Linking ISSN: 21686165 NLM ISO Abbreviation: JAMA Ophthalmol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2168-6173
DOI:10.1001/jamaophthalmol.2026.1380