Improving Efficiency in Geographic Atrophy Clinical Trials Using Run-In Phases or Single-Arm Designs.

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Title: Improving Efficiency in Geographic Atrophy Clinical Trials Using Run-In Phases or Single-Arm Designs.
Authors: Hou J; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland., von der Emde L; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.; Department of Ophthalmology, University of Bonn, Bonn, Germany., Mukherjee S; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland., Vance E; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland., de Silva T; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland., Shen LL; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina.; Department of Ophthalmology, University of California, San Francisco., Keenan TDL; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Source: JAMA ophthalmology [JAMA Ophthalmol] 2026 Jun 01; Vol. 144 (6), pp. 529-535.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589539 Publication Model: Print Cited Medium: Internet ISSN: 2168-6173 (Electronic) Linking ISSN: 21686165 NLM ISO Abbreviation: JAMA Ophthalmol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hou+J%22">Hou J</searchLink>; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22von+der+Emde+L%22">von der Emde L</searchLink>; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.; Department of Ophthalmology, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Vance+E%22">Vance E</searchLink>; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22de+Silva+T%22">de Silva T</searchLink>; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Shen+LL%22">Shen LL</searchLink>; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina.; Department of Ophthalmology, University of California, San Francisco.<br /><searchLink fieldCode="AU" term="%22Keenan+TDL%22">Keenan TDL</searchLink>; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
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  Data: <searchLink fieldCode="JN" term="%22101589539%22">JAMA ophthalmology</searchLink> [JAMA Ophthalmol] 2026 Jun 01; Vol. 144 (6), pp. 529-535.
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        Value: 10.1001/jamaophthalmol.2026.1380
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              Text: 2026 Jun 01
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