Deciphering and targeting the pathogenic circuit of nonlytic hepatitis E virus infection using macrophage-augmented organoids.

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Title: Deciphering and targeting the pathogenic circuit of nonlytic hepatitis E virus infection using macrophage-augmented organoids.
Authors: Liu K; Department of Orthopaedics, Chongqing General Hospital, Chongqing University, Chongqing 401121, China.; Department of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The Netherlands., Zhao Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands., Wang Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands., Tsikari T; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden 2333ZA, The Netherlands., Offermans DM; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands., Li X; Department of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The Netherlands.; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands., V Orlova V; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden 2333ZA, The Netherlands., van der Laan LJW; Department of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The Netherlands.; Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Biomaterials and Tissue Biomechanics, Delft University of Technology, Delft 2628CD, the Netherlands., Pan Q; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2603870123. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2603870123