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Deciphering and targeting the pathogenic circuit of nonlytic hepatitis E virus infection using macrophage-augmented organoids.

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Title: Deciphering and targeting the pathogenic circuit of nonlytic hepatitis E virus infection using macrophage-augmented organoids.
Authors: Liu K; Department of Orthopaedics, Chongqing General Hospital, Chongqing University, Chongqing 401121, China.; Department of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The Netherlands., Zhao Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands., Wang Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands., Tsikari T; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden 2333ZA, The Netherlands., Offermans DM; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands., Li X; Department of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The Netherlands.; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands., V Orlova V; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden 2333ZA, The Netherlands., van der Laan LJW; Department of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The Netherlands.; Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Biomaterials and Tissue Biomechanics, Delft University of Technology, Delft 2628CD, the Netherlands., Pan Q; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2603870123. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Deciphering and targeting the pathogenic circuit of nonlytic hepatitis E virus infection using macrophage-augmented organoids.
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  Data: <searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Department of Orthopaedics, Chongqing General Hospital, Chongqing University, Chongqing 401121, China.; Department of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tsikari+T%22">Tsikari T</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden 2333ZA, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Offermans+DM%22">Offermans DM</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The Netherlands.; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands.<br /><searchLink fieldCode="AU" term="%22V+Orlova+V%22">V Orlova V</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden 2333ZA, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Laan+LJW%22">van der Laan LJW</searchLink>; Department of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The Netherlands.; Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Biomaterials and Tissue Biomechanics, Delft University of Technology, Delft 2628CD, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pan+Q%22">Pan Q</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2603870123. <i>Date of Electronic Publication: </i>2026 May 14.
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        Value: 10.1073/pnas.2603870123
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              Text: 2026 May 19
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