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Pharmacologic activation of PHD2 sensitizes non-small cell lung cancer cells to osimertinib.

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Title: Pharmacologic activation of PHD2 sensitizes non-small cell lung cancer cells to osimertinib.
Authors: Kim JS; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Republic of Korea., Abeysiriwardhana HNI; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Republic of Korea., Kim DK; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Republic of Korea., Yoon TH; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Republic of Korea., Choi JH; Department of Biochemistry, School of Medicine, Jeju National University, Jeju 63243, Republic of Korea., Liang Z; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea., Kim JW; Jeju Institute of Korean Medicine, Jeju 63309, Republic of Korea., Liu KH; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea., Lim Y; Division of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea., Yu JS; College of Pharmacy, Jeju National University, Jeju 63243, Republic of Korea., Cho SK; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Republic of Korea; Faculty of Biotechnology, College of Applied Life Sciences, SARI, Jeju National University, Jeju 63243, Republic of Korea. Electronic address: somikim@jejunu.ac.kr., Cho M; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Republic of Korea; Department of Biochemistry, School of Medicine, Jeju National University, Jeju 63243, Republic of Korea; ACHEMBIO Inc., Jeju 63169, Republic of Korea. Electronic address: moonjae.cho@jejunu.ac.kr.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 Jul; Vol. 200, pp. 119443. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1950-6007
DOI:10.1016/j.biopha.2026.119443