Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a systematic review with meta-analysis and trial sequential analysis.

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Title: Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a systematic review with meta-analysis and trial sequential analysis.
Authors: Petersen JJ; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark johanne.juul.petersen@ctu.dk.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Faltermeier P; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark., Juul S; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark.; Mental Health Services in the Capital Region of Denmark, Psykoterapeutisk Center Stolpegard, Gentofte, Denmark.; Department of Psychology, University of Copenhagen, Copenhagen, Denmark., Kamp CB; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark., Sillassen CDB; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.; Department of Cardiology, Central and West Zealand Hospital, Slagelse, Denmark., Dos Santos TJ; Unit of Pediatrics, Hospital Vithas Almería, Instituto Hispalense de Pediatría SL, Seville, Spain.; Department of Nursing Physiotherapy and Medicine, Faculty of Health Sciences, University of Almeria, Almería, Spain., Jakobsen JC; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Source: BMJ open [BMJ Open] 2026 May 14; Vol. 16 (5), pp. e100186. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2044-6055
DOI:10.1136/bmjopen-2025-100186