KLRG1 silencing increases the efficacy of CAR NK cell therapy against colon cancer via SHP-2/ZAP-70/NF-κB signal pathway.

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Title: KLRG1 silencing increases the efficacy of CAR NK cell therapy against colon cancer via SHP-2/ZAP-70/NF-κB signal pathway.
Authors: Chen Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Farooq MA; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.; Department of Precision Medicine, The first Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523000, China., Hui X; The First Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, 510120, China.; Guangzhou National Laboratory, Guangzhou, 510005, China., Huang Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Hu Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Xue M; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Ajmal I; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.; Guangdong Provincial key laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Lab Technology, Guangdong Medical University, Dongguan, 510260, China., Ren Y; College of Life Science, Xinjiang Normal University, Urumqi, China., Ji Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Wang C; Department of Oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China. wangchenchina@126.com., Jiang W; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China. wzjiang@bio.ecnu.edu.cn.; Shanghai NTBIO Therapeutics Co., Ltd., Shanghai, 200241, China. wzjiang@bio.ecnu.edu.cn.
Source: Journal of translational medicine [J Transl Med] 2026 May 14; Vol. 24 (1). Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-026-08267-y