Heterozygous loss-of-function alleles associate the conserved 3'-5' exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5-fluorouracil.

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Title:	Heterozygous loss-of-function alleles associate the conserved 3'-5' exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5-fluorouracil.
Authors:	Sain R; Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Univ Rennes, Rennes, France., Le Page Y; Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Univ Rennes, Rennes, France., Percevault F; Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Univ Rennes, Rennes, France., Becker E; Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Univ Rennes, Rennes, France., Negroni L; ESBS, -BCS-UMR7242, Illkirch, France., Fernandez A; National Centre of Biotechnology (CNB-CSIC), Madrid, Spain.; Biomedical Research Networking Center on Rare Diseases (CIBERER-ISCIII), Madrid, Spain., Cantero M; National Centre of Biotechnology (CNB-CSIC), Madrid, Spain.; Biomedical Research Networking Center on Rare Diseases (CIBERER-ISCIII), Madrid, Spain., Muñoz-Santos D; National Centre of Biotechnology (CNB-CSIC), Madrid, Spain.; Biomedical Research Networking Center on Rare Diseases (CIBERER-ISCIII), Madrid, Spain.; Department of Medicine. Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Madrid, Spain., Montoliu L; National Centre of Biotechnology (CNB-CSIC), Madrid, Spain.; Biomedical Research Networking Center on Rare Diseases (CIBERER-ISCIII), Madrid, Spain., Garnier C; Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Univ Rennes, Rennes, France., Primig M; Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Univ Rennes, Rennes, France.
Source:	Molecular oncology [Mol Oncol] 2026 May 15. Date of Electronic Publication: 2026 May 15.
Publication Type:	Journal Article
Journal Info:	Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE
Database:	MEDLINE Ultimate

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ISSN:	1878-0261
DOI:	10.1002/1878-0261.70239