Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway.

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Title: Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway.
Authors: Feng H; School of Pet Science and Technology, Henan Vocational College of Agriculture, Zhengzhou, Henan 451450, P.R. China., He L; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China., Umar T; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China., Wang H; School of Pet Science and Technology, Henan Vocational College of Agriculture, Zhengzhou, Henan 451450, P.R. China., Gao Y; School of Pet Science and Technology, Henan Vocational College of Agriculture, Zhengzhou, Henan 451450, P.R. China., Chen G; School of Pet Science and Technology, Henan Vocational College of Agriculture, Zhengzhou, Henan 451450, P.R. China., Sun P; School of Pet Science and Technology, Henan Vocational College of Agriculture, Zhengzhou, Henan 451450, P.R. China., Yin L; School of Pet Science and Technology, Henan Vocational College of Agriculture, Zhengzhou, Henan 451450, P.R. China., Zhao W; School of Pet Science and Technology, Henan Vocational College of Agriculture, Zhengzhou, Henan 451450, P.R. China., Lu H; School of Pet Science and Technology, Henan Vocational College of Agriculture, Zhengzhou, Henan 451450, P.R. China., Deng G; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China., Qiu C; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China.
Source: Oncology reports [Oncol Rep] 2026 Jul; Vol. 56 (1). Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1791-2431
DOI:10.3892/or.2026.9136