PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model.

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Title: PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model.
Authors: Jhaldiyal A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Kumari M; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Guttman LC; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Tripathi T; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Khan MR; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Wang J; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Biswas D; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Pasupuleti A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Aggarwal A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Pandya S; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Chou SC; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Panicker N; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Monghekar A; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Albert M; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Bekris LM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98104.; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH 44195., Leverenz JB; Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195.; Department of Neurology, Cleveland Clinic, Cleveland, OH 44195.; Geriatric Research Education and Clinical Center, Veteran Affairs Puget Sound Health Care System (S-182), Seattle, WA 98108.; Department of Neurology, University of Washington, Seattle, WA 98195., Kam TI; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Dawson TM; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Dawson VL; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2525028123. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2525028123