PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model.
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| Title: | PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model. |
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| Authors: | Jhaldiyal A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Kumari M; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Guttman LC; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Tripathi T; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Khan MR; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Wang J; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Biswas D; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Pasupuleti A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Aggarwal A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Pandya S; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Chou SC; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Panicker N; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Monghekar A; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Albert M; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Bekris LM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98104.; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH 44195., Leverenz JB; Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195.; Department of Neurology, Cleveland Clinic, Cleveland, OH 44195.; Geriatric Research Education and Clinical Center, Veteran Affairs Puget Sound Health Care System (S-182), Seattle, WA 98108.; Department of Neurology, University of Washington, Seattle, WA 98195., Kam TI; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Dawson TM; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205., Dawson VL; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2525028123. Date of Electronic Publication: 2026 May 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42139290 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Jhaldiyal+A%22">Jhaldiyal A</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Kumari+M%22">Kumari M</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Guttman+LC%22">Guttman LC</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Tripathi+T%22">Tripathi T</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Khan+MR%22">Khan MR</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Biswas+D%22">Biswas D</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Pasupuleti+A%22">Pasupuleti A</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Aggarwal+A%22">Aggarwal A</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Pandya+S%22">Pandya S</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Chou+SC%22">Chou SC</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Panicker+N%22">Panicker N</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Monghekar+A%22">Monghekar A</searchLink>; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Albert+M%22">Albert M</searchLink>; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Bekris+LM%22">Bekris LM</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98104.; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH 44195.<br /><searchLink fieldCode="AU" term="%22Leverenz+JB%22">Leverenz JB</searchLink>; Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195.; Department of Neurology, Cleveland Clinic, Cleveland, OH 44195.; Geriatric Research Education and Clinical Center, Veteran Affairs Puget Sound Health Care System (S-182), Seattle, WA 98108.; Department of Neurology, University of Washington, Seattle, WA 98195.<br /><searchLink fieldCode="AU" term="%22Kam+TI%22">Kam TI</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Dawson+TM%22">Dawson TM</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.<br /><searchLink fieldCode="AU" term="%22Dawson+VL%22">Dawson VL</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2525028123. <i>Date of Electronic Publication: </i>2026 May 15. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22National+Academy+of+Sciences%22">National Academy of Sciences </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7505876 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1091-6490 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200278424%22">00278424 </searchLink><i>NLM ISO Abbreviation: </i>Proc Natl Acad Sci U S A <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42139290 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2525028123 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e2525028123 Titles: – TitleFull: PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jhaldiyal A – PersonEntity: Name: NameFull: Kumari M – PersonEntity: Name: NameFull: Guttman LC – PersonEntity: Name: NameFull: Tripathi T – PersonEntity: Name: NameFull: Khan MR – PersonEntity: Name: NameFull: Wang J – PersonEntity: Name: NameFull: Biswas D – PersonEntity: Name: NameFull: Pasupuleti A – PersonEntity: Name: NameFull: Aggarwal A – PersonEntity: Name: NameFull: Pandya S – PersonEntity: Name: NameFull: Chou SC – PersonEntity: Name: NameFull: Panicker N – PersonEntity: Name: NameFull: Monghekar A – PersonEntity: Name: NameFull: Albert M – PersonEntity: Name: NameFull: Bekris LM – PersonEntity: Name: NameFull: Leverenz JB – PersonEntity: Name: NameFull: Kam TI – PersonEntity: Name: NameFull: Dawson TM – PersonEntity: Name: NameFull: Dawson VL IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 05 Text: 2026 May 19 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1091-6490 Numbering: – Type: volume Value: 123 – Type: issue Value: 20 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
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