Biological subphenotypes in severe acute hypoxaemic respiratory failure and acute respiratory distress syndrome using rapid prospective classification (SPARC) in the USA: a multicentre, observational, study.

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Title: Biological subphenotypes in severe acute hypoxaemic respiratory failure and acute respiratory distress syndrome using rapid prospective classification (SPARC) in the USA: a multicentre, observational, study.
Authors: Files DC; Internal Medicine-Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, NC, USA. Electronic address: clark.files@wfusm.edu., Matthay MA; Cardiovascular Research Institute, Departments of Medicine and Anesthesia, University of California San Francisco, San Francisco, CA, USA., Chapple AG; Clinical Data Management and Statistics, Quantum Leap Healthcare Collaborative, San Francisco, CA, USA., Barragan AB; Clinical Data Management and Statistics, Quantum Leap Healthcare Collaborative, San Francisco, CA, USA., Mabrey L; Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA., Gibbs KW; Internal Medicine-Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Krall J; Internal Medicine-Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Aggarwal NR; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Burnham EL; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Liu KD; Departments of Medicine and Anesthesia, University of California San Francisco, San Francisco, CA, USA., Meyer NJ; Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Nates JL; Critical Care Department, Division of Anesthesiology, Critical Care, and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Youssef FA; Department of Internal Medicine, Division of Pulmonary and Critical Care, Memorial Care Long Beach Medical Center, Long Beach, CA, USA., Friedman E; Department of Medicine, Main Line Health, Wynnewood, PA, USA., Kett DH; Division of Pulmonary, Critical Care and Sleep Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA., Koff J; Department of Medicine, Yale University, New Haven CT, USA., Russell DW; Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA., Calfee CS; Cardiovascular Research Institute, Departments of Medicine and Anesthesia, University of California San Francisco, San Francisco, CA, USA., Eklund M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Esserman LJ; Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
Source: The Lancet. Respiratory medicine [Lancet Respir Med] 2026 Jul; Vol. 14 (7), pp. 601-608. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article; Observational Study; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-2619
DOI:10.1016/S2213-2600(26)00083-4