Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder.

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Title: Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder.
Authors: Hou L; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA. leihou@bu.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA. leihou@bu.edu.; Department of Medicine, Biomedical Genetics Section, Boston University School of Medicine, Boston, MA, USA. leihou@bu.edu., Li Y; School of Computer Science, McGill University, Montreal, QC, Canada., Xiong X; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tanigawa Y; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Park Y; Department of Pathology and Laboratory Medicine, Department of Statistics, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, Vancouver, BC, Canada., Lenz SW; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA., Grayson A; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lee JH; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Ryu E; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Olson JE; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Biernacka JM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Frye MA; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Ordog T; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA. Ordog.Tamas@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Ordog.Tamas@mayo.edu.; Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Ordog.Tamas@mayo.edu., Kellis M; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA. manoli@mit.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA. manoli@mit.edu.
Source: Nature communications [Nat Commun] 2026 May 15. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72543-0