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Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder.

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Title: Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder.
Authors: Hou L; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA. leihou@bu.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA. leihou@bu.edu.; Department of Medicine, Biomedical Genetics Section, Boston University School of Medicine, Boston, MA, USA. leihou@bu.edu., Li Y; School of Computer Science, McGill University, Montreal, QC, Canada., Xiong X; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tanigawa Y; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Park Y; Department of Pathology and Laboratory Medicine, Department of Statistics, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, Vancouver, BC, Canada., Lenz SW; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA., Grayson A; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lee JH; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Ryu E; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Olson JE; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Biernacka JM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Frye MA; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Ordog T; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA. Ordog.Tamas@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Ordog.Tamas@mayo.edu.; Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Ordog.Tamas@mayo.edu., Kellis M; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA. manoli@mit.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA. manoli@mit.edu.
Source: Nature communications [Nat Commun] 2026 May 15. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hou+L%22">Hou L</searchLink>; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA. leihou@bu.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA. leihou@bu.edu.; Department of Medicine, Biomedical Genetics Section, Boston University School of Medicine, Boston, MA, USA. leihou@bu.edu.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; School of Computer Science, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Xiong+X%22">Xiong X</searchLink>; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tanigawa+Y%22">Tanigawa Y</searchLink>; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Park+Y%22">Park Y</searchLink>; Department of Pathology and Laboratory Medicine, Department of Statistics, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Lenz+SW%22">Lenz SW</searchLink>; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Grayson+A%22">Grayson A</searchLink>; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Ryu+E%22">Ryu E</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Olson+JE%22">Olson JE</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Biernacka+JM%22">Biernacka JM</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Frye+MA%22">Frye MA</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Ordog+T%22">Ordog T</searchLink>; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA. Ordog.Tamas@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Ordog.Tamas@mayo.edu.; Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Ordog.Tamas@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Kellis+M%22">Kellis M</searchLink>; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA. manoli@mit.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA. manoli@mit.edu.
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