Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia.

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Title: Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia.
Authors: Flores-Aguilar L; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Zaikos TD; Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA, USA., Rivera I; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Wright ST; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Lou J; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Gawronski B; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Gonzalez L; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Berry JV; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.; Department of Neurology, University of California Irvine, Irvine, CA, USA., Rouanet J; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Edwards NC; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neuroscience, Columbia University, New York, NY, USA., Hoang DK; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Wood K; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Granholm AC; Department of Neurosurgery, University of Colorado Anschutz Medical Center, Aurora, CO, USA., Mufson EJ; Department of Translational Neuroscience and Neurology, Barrow Neurological Institute, Phoenix, AZ, USA., Monuki ES; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.; Sue and Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA, USA., Ikonomovic MD; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, VA Pittsburgh HS, Pittsburgh, PA, USA., Kofler J; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Doran EW; Department of Pediatrics, University of California Irvine, Orange, CA, USA., Lott IT; Department of Pediatrics, University of California Irvine, Orange, CA, USA., Totoiu MO; Department of Pediatrics, University of California Irvine, Orange, CA, USA., Hom CL; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA., Lai F; Department of Neurology, Harvard University, Cambridge, MA, USA., Yong WH; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Schmitt FA; Department of Neurology, Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA., Harp J; Department of Neurology, Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA., Nelson PT; Department of Neurology, Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA.; Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Kentucky, Lexington, KY, USA., Gutierrez J; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Lao PJ; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Wilcock DM; Department of Neurology, Indiana University, Bloomington, IN, USA., Brickman AM; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Head E; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA. heade@uci.edu.
Corporate Authors: Alzheimer’s Biomarker Consortium-Down syndrome (ABC-DS)
Source: Acta neuropathologica [Acta Neuropathol] 2026 May 15; Vol. 151 (1). Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0533
DOI:10.1007/s00401-026-03028-z