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Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia.

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Title: Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia.
Authors: Flores-Aguilar L; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Zaikos TD; Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA, USA., Rivera I; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Wright ST; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Lou J; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Gawronski B; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Gonzalez L; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Berry JV; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.; Department of Neurology, University of California Irvine, Irvine, CA, USA., Rouanet J; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Edwards NC; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neuroscience, Columbia University, New York, NY, USA., Hoang DK; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Wood K; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Granholm AC; Department of Neurosurgery, University of Colorado Anschutz Medical Center, Aurora, CO, USA., Mufson EJ; Department of Translational Neuroscience and Neurology, Barrow Neurological Institute, Phoenix, AZ, USA., Monuki ES; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.; Sue and Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA, USA., Ikonomovic MD; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, VA Pittsburgh HS, Pittsburgh, PA, USA., Kofler J; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Doran EW; Department of Pediatrics, University of California Irvine, Orange, CA, USA., Lott IT; Department of Pediatrics, University of California Irvine, Orange, CA, USA., Totoiu MO; Department of Pediatrics, University of California Irvine, Orange, CA, USA., Hom CL; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA., Lai F; Department of Neurology, Harvard University, Cambridge, MA, USA., Yong WH; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA., Schmitt FA; Department of Neurology, Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA., Harp J; Department of Neurology, Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA., Nelson PT; Department of Neurology, Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA.; Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Kentucky, Lexington, KY, USA., Gutierrez J; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Lao PJ; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Wilcock DM; Department of Neurology, Indiana University, Bloomington, IN, USA., Brickman AM; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Head E; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA. heade@uci.edu.
Corporate Authors: Alzheimer’s Biomarker Consortium-Down syndrome (ABC-DS)
Source: Acta neuropathologica [Acta Neuropathol] 2026 May 15; Vol. 151 (1). Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia.
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  Data: <searchLink fieldCode="AU" term="%22Flores-Aguilar+L%22">Flores-Aguilar L</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Zaikos+TD%22">Zaikos TD</searchLink>; Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rivera+I%22">Rivera I</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Wright+ST%22">Wright ST</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Lou+J%22">Lou J</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Gawronski+B%22">Gawronski B</searchLink>; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+L%22">Gonzalez L</searchLink>; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Berry+JV%22">Berry JV</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.; Department of Neurology, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rouanet+J%22">Rouanet J</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+NC%22">Edwards NC</searchLink>; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neuroscience, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hoang+DK%22">Hoang DK</searchLink>; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wood+K%22">Wood K</searchLink>; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Granholm+AC%22">Granholm AC</searchLink>; Department of Neurosurgery, University of Colorado Anschutz Medical Center, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Mufson+EJ%22">Mufson EJ</searchLink>; Department of Translational Neuroscience and Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Monuki+ES%22">Monuki ES</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.; Sue and Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ikonomovic+MD%22">Ikonomovic MD</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, VA Pittsburgh HS, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kofler+J%22">Kofler J</searchLink>; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Doran+EW%22">Doran EW</searchLink>; Department of Pediatrics, University of California Irvine, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lott+IT%22">Lott IT</searchLink>; Department of Pediatrics, University of California Irvine, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Totoiu+MO%22">Totoiu MO</searchLink>; Department of Pediatrics, University of California Irvine, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hom+CL%22">Hom CL</searchLink>; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lai+F%22">Lai F</searchLink>; Department of Neurology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yong+WH%22">Yong WH</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Schmitt+FA%22">Schmitt FA</searchLink>; Department of Neurology, Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Harp+J%22">Harp J</searchLink>; Department of Neurology, Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+PT%22">Nelson PT</searchLink>; Department of Neurology, Sanders-Brown Center On Aging, University of Kentucky, Lexington, KY, USA.; Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Gutierrez+J%22">Gutierrez J</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lao+PJ%22">Lao PJ</searchLink>; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wilcock+DM%22">Wilcock DM</searchLink>; Department of Neurology, Indiana University, Bloomington, IN, USA.<br /><searchLink fieldCode="AU" term="%22Brickman+AM%22">Brickman AM</searchLink>; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, 92697, USA. heade@uci.edu.
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2026 May 15; Vol. 151 (1). <i>Date of Electronic Publication: </i>2026 May 15.
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