Discovery of Kv3.1 channel inhibitors reveals VU0521426 as a state-dependent inactivator preferentially active against pathogenic gain-of-function mutants.
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| Title: | Discovery of Kv3.1 channel inhibitors reveals VU0521426 as a state-dependent inactivator preferentially active against pathogenic gain-of-function mutants. |
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| Authors: | Chandrappa RU; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States., Satpute Janve V; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Days EL; High Throughput Screening Core Facility, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, United States., Denton JS; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States.; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States. |
| Source: | American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2026 Jun 01; Vol. 330 (6), pp. C1788-C1799. Date of Electronic Publication: 2026 May 15. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1522-1563 |
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| DOI: | 10.1152/ajpcell.00239.2026 |
