Discovery of Kv3.1 channel inhibitors reveals VU0521426 as a state-dependent inactivator preferentially active against pathogenic gain-of-function mutants.
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| Title: | Discovery of Kv3.1 channel inhibitors reveals VU0521426 as a state-dependent inactivator preferentially active against pathogenic gain-of-function mutants. |
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| Authors: | Chandrappa RU; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States., Satpute Janve V; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Days EL; High Throughput Screening Core Facility, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, United States., Denton JS; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States.; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States. |
| Source: | American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2026 Jun 01; Vol. 330 (6), pp. C1788-C1799. Date of Electronic Publication: 2026 May 15. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42141755 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Discovery of Kv3.1 channel inhibitors reveals VU0521426 as a state-dependent inactivator preferentially active against pathogenic gain-of-function mutants. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chandrappa+RU%22">Chandrappa RU</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States.<br /><searchLink fieldCode="AU" term="%22Satpute+Janve+V%22">Satpute Janve V</searchLink>; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.<br /><searchLink fieldCode="AU" term="%22Days+EL%22">Days EL</searchLink>; High Throughput Screening Core Facility, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, United States.<br /><searchLink fieldCode="AU" term="%22Denton+JS%22">Denton JS</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States.; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100901225%22">American journal of physiology. Cell physiology</searchLink> [Am J Physiol Cell Physiol] 2026 Jun 01; Vol. 330 (6), pp. C1788-C1799. <i>Date of Electronic Publication: </i>2026 May 15. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901225 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1563 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203636143%22">03636143 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Cell Physiol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42141755 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1152/ajpcell.00239.2026 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: C1788 Titles: – TitleFull: Discovery of Kv3.1 channel inhibitors reveals VU0521426 as a state-dependent inactivator preferentially active against pathogenic gain-of-function mutants. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chandrappa RU – PersonEntity: Name: NameFull: Satpute Janve V – PersonEntity: Name: NameFull: Days EL – PersonEntity: Name: NameFull: Denton JS IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1522-1563 Numbering: – Type: volume Value: 330 – Type: issue Value: 6 Titles: – TitleFull: American journal of physiology. Cell physiology Type: main |
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