Clinical Predictors of Antidepressant Effects of Ketamine and Esketamine in Treatment-Resistant Unipolar and Bipolar Depression: A Systematic Review.

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Title: Clinical Predictors of Antidepressant Effects of Ketamine and Esketamine in Treatment-Resistant Unipolar and Bipolar Depression: A Systematic Review.
Authors: Syed OA; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. omer.syed@mail.utoronto.ca.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. omer.syed@mail.utoronto.ca., Sobolenko V; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Nestor SM; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Husain MI; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada., Lipsman N; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Alam F; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada., Giacobbe P; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Kerr Chair in Interventional Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Source: CNS drugs [CNS Drugs] 2026 Jul; Vol. 40 (7), pp. 949-972. Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1179-1934
DOI:10.1007/s40263-026-01296-7