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Clinical Predictors of Antidepressant Effects of Ketamine and Esketamine in Treatment-Resistant Unipolar and Bipolar Depression: A Systematic Review.

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Title: Clinical Predictors of Antidepressant Effects of Ketamine and Esketamine in Treatment-Resistant Unipolar and Bipolar Depression: A Systematic Review.
Authors: Syed OA; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. omer.syed@mail.utoronto.ca.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. omer.syed@mail.utoronto.ca., Sobolenko V; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Nestor SM; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Husain MI; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada., Lipsman N; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Alam F; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada., Giacobbe P; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Kerr Chair in Interventional Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Source: CNS drugs [CNS Drugs] 2026 Jul; Vol. 40 (7), pp. 949-972. Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical Predictors of Antidepressant Effects of Ketamine and Esketamine in Treatment-Resistant Unipolar and Bipolar Depression: A Systematic Review.
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  Data: <searchLink fieldCode="AU" term="%22Syed+OA%22">Syed OA</searchLink>; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. omer.syed@mail.utoronto.ca.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. omer.syed@mail.utoronto.ca.<br /><searchLink fieldCode="AU" term="%22Sobolenko+V%22">Sobolenko V</searchLink>; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Nestor+SM%22">Nestor SM</searchLink>; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Husain+MI%22">Husain MI</searchLink>; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lipsman+N%22">Lipsman N</searchLink>; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Alam+F%22">Alam F</searchLink>; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Giacobbe+P%22">Giacobbe P</searchLink>; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Kerr Chair in Interventional Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
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  Data: <searchLink fieldCode="JN" term="%229431220%22">CNS drugs</searchLink> [CNS Drugs] 2026 Jul; Vol. 40 (7), pp. 949-972. <i>Date of Electronic Publication: </i>2026 May 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>9431220 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-1934 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211727047%22">11727047 </searchLink><i>NLM ISO Abbreviation: </i>CNS Drugs <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s40263-026-01296-7
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              Text: 2026 Jul
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