Synthesis of steroids fused with a pyridine at C11-C12 to accommodate the active site ceiling of cytochrome P450 8B1.

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Title: Synthesis of steroids fused with a pyridine at C11-C12 to accommodate the active site ceiling of cytochrome P450 8B1.
Authors: Ho TM; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA., Frydendall EK; Departments of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., Zhou J; Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA., Offei SD; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA., Arman HD; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA. Electronic address: hadi.arman@utsa.edu., Scott EE; Departments of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA; Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Biological Chemistry and the Programs in Chemical Biology and Biophysics, University of Michigan, Ann Arbor, MI 48109, USA., Yoshimoto FK; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
Source: Steroids [Steroids] 2026 May 15; Vol. 233-234, pp. 109796. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0404536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5867 (Electronic) Linking ISSN: 0039128X NLM ISO Abbreviation: Steroids Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-5867
DOI:10.1016/j.steroids.2026.109796