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Synthesis of steroids fused with a pyridine at C11-C12 to accommodate the active site ceiling of cytochrome P450 8B1.

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Title: Synthesis of steroids fused with a pyridine at C11-C12 to accommodate the active site ceiling of cytochrome P450 8B1.
Authors: Ho TM; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA., Frydendall EK; Departments of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., Zhou J; Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA., Offei SD; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA., Arman HD; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA. Electronic address: hadi.arman@utsa.edu., Scott EE; Departments of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA; Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Biological Chemistry and the Programs in Chemical Biology and Biophysics, University of Michigan, Ann Arbor, MI 48109, USA., Yoshimoto FK; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
Source: Steroids [Steroids] 2026 May 15; Vol. 233-234, pp. 109796. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0404536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5867 (Electronic) Linking ISSN: 0039128X NLM ISO Abbreviation: Steroids Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis of steroids fused with a pyridine at C11-C12 to accommodate the active site ceiling of cytochrome P450 8B1.
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  Data: <searchLink fieldCode="AU" term="%22Ho+TM%22">Ho TM</searchLink>; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.<br /><searchLink fieldCode="AU" term="%22Frydendall+EK%22">Frydendall EK</searchLink>; Departments of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Offei+SD%22">Offei SD</searchLink>; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.<br /><searchLink fieldCode="AU" term="%22Arman+HD%22">Arman HD</searchLink>; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA. Electronic address: hadi.arman@utsa.edu.<br /><searchLink fieldCode="AU" term="%22Scott+EE%22">Scott EE</searchLink>; Departments of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA; Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Biological Chemistry and the Programs in Chemical Biology and Biophysics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Yoshimoto+FK%22">Yoshimoto FK</searchLink>; Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
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  Data: <searchLink fieldCode="JN" term="%220404536%22">Steroids</searchLink> [Steroids] 2026 May 15; Vol. 233-234, pp. 109796. <i>Date of Electronic Publication: </i>2026 May 15.
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        Value: 10.1016/j.steroids.2026.109796
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        Text: English
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      – TitleFull: Synthesis of steroids fused with a pyridine at C11-C12 to accommodate the active site ceiling of cytochrome P450 8B1.
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              Text: 2026 May 15
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              Value: 233-234
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