Postoperative delirium in hip fracture patients linked to epigenetic alterations in inflammatory and immune pathways: a genome-wide DNA methylation study.
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| Title: | Postoperative delirium in hip fracture patients linked to epigenetic alterations in inflammatory and immune pathways: a genome-wide DNA methylation study. |
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| Authors: | Seki T; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan., Nishitani S; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Research Center for Child Mental Development, University of Fukui, Fukui, Japan.; Division of Developmental Higher Brain Functions, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, and University of Fukui, Osaka, Japan.; Life Science Innovation Center, School of Medical Sciences, University of Fukui, Fukui, Japan., Nishizawa Y; Department of Psychiatry, School of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan., Yamanishi K; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Neuropsychiatry, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan., Shimura A; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan., Nishiguchi T; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan., Ishii T; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; iPS Cell-Based Drug Discovery Group, Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Osaka, Osaka, Japan., Aoyama B; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Division of Anesthesiology, National Hospital Organization Kochi Hospital, Kochi, Kochi, Japan.; Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Nankoku, Kochi, Japan., Santiago TA; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA., Phuong NJ; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA., Gorantla N; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA., Nguyen HD; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA., Takeda R; Advanced Clinical Specialist Center, Kameda Medical Center, Kamogawa, Chiba, Japan., Kameoka T; Department of Orthopedics, Kameda Medical Center, Kamogawa, Chiba, Japan., Inoue T; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan., Sugiyama D; Department of Anesthesia, Kameda Medical Center, Kamogawa, Chiba, Japan.; Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Ueda K; Department of Anesthesia, Kameda Medical Center, Kamogawa, Chiba, Japan.; Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Yamanashi T; Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan. yamatake@tottori-u.ac.jp., Shinozaki G; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA. gens@stanford.edu. |
| Source: | Translational psychiatry [Transl Psychiatry] 2026 May 16; Vol. 16 (1). Date of Electronic Publication: 2026 May 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2158-3188 |
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| DOI: | 10.1038/s41398-026-04067-6 |
