Postoperative delirium in hip fracture patients linked to epigenetic alterations in inflammatory and immune pathways: a genome-wide DNA methylation study.
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| Title: | Postoperative delirium in hip fracture patients linked to epigenetic alterations in inflammatory and immune pathways: a genome-wide DNA methylation study. |
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| Authors: | Seki T; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan., Nishitani S; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Research Center for Child Mental Development, University of Fukui, Fukui, Japan.; Division of Developmental Higher Brain Functions, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, and University of Fukui, Osaka, Japan.; Life Science Innovation Center, School of Medical Sciences, University of Fukui, Fukui, Japan., Nishizawa Y; Department of Psychiatry, School of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan., Yamanishi K; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Neuropsychiatry, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan., Shimura A; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan., Nishiguchi T; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan., Ishii T; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; iPS Cell-Based Drug Discovery Group, Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Osaka, Osaka, Japan., Aoyama B; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Division of Anesthesiology, National Hospital Organization Kochi Hospital, Kochi, Kochi, Japan.; Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Nankoku, Kochi, Japan., Santiago TA; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA., Phuong NJ; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA., Gorantla N; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA., Nguyen HD; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA., Takeda R; Advanced Clinical Specialist Center, Kameda Medical Center, Kamogawa, Chiba, Japan., Kameoka T; Department of Orthopedics, Kameda Medical Center, Kamogawa, Chiba, Japan., Inoue T; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan., Sugiyama D; Department of Anesthesia, Kameda Medical Center, Kamogawa, Chiba, Japan.; Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Ueda K; Department of Anesthesia, Kameda Medical Center, Kamogawa, Chiba, Japan.; Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Yamanashi T; Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan. yamatake@tottori-u.ac.jp., Shinozaki G; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA. gens@stanford.edu. |
| Source: | Translational psychiatry [Transl Psychiatry] 2026 May 16; Vol. 16 (1). Date of Electronic Publication: 2026 May 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42143058 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Postoperative delirium in hip fracture patients linked to epigenetic alterations in inflammatory and immune pathways: a genome-wide DNA methylation study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Seki+T%22">Seki T</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishitani+S%22">Nishitani S</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Research Center for Child Mental Development, University of Fukui, Fukui, Japan.; Division of Developmental Higher Brain Functions, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, and University of Fukui, Osaka, Japan.; Life Science Innovation Center, School of Medical Sciences, University of Fukui, Fukui, Japan.<br /><searchLink fieldCode="AU" term="%22Nishizawa+Y%22">Nishizawa Y</searchLink>; Department of Psychiatry, School of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamanishi+K%22">Yamanishi K</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Neuropsychiatry, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Shimura+A%22">Shimura A</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishiguchi+T%22">Nishiguchi T</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.<br /><searchLink fieldCode="AU" term="%22Ishii+T%22">Ishii T</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; iPS Cell-Based Drug Discovery Group, Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co., Ltd., Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Aoyama+B%22">Aoyama B</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.; Division of Anesthesiology, National Hospital Organization Kochi Hospital, Kochi, Kochi, Japan.; Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Nankoku, Kochi, Japan.<br /><searchLink fieldCode="AU" term="%22Santiago+TA%22">Santiago TA</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Phuong+NJ%22">Phuong NJ</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gorantla+N%22">Gorantla N</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+HD%22">Nguyen HD</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Takeda+R%22">Takeda R</searchLink>; Advanced Clinical Specialist Center, Kameda Medical Center, Kamogawa, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Kameoka+T%22">Kameoka T</searchLink>; Department of Orthopedics, Kameda Medical Center, Kamogawa, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+T%22">Inoue T</searchLink>; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sugiyama+D%22">Sugiyama D</searchLink>; Department of Anesthesia, Kameda Medical Center, Kamogawa, Chiba, Japan.; Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Ueda+K%22">Ueda K</searchLink>; Department of Anesthesia, Kameda Medical Center, Kamogawa, Chiba, Japan.; Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Yamanashi+T%22">Yamanashi T</searchLink>; Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan. yamatake@tottori-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Shinozaki+G%22">Shinozaki G</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Palo Alto, CA, USA. gens@stanford.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101562664%22">Translational psychiatry</searchLink> [Transl Psychiatry] 2026 May 16; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 May 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101562664 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2158-3188 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221583188%22">21583188 </searchLink><i>NLM ISO Abbreviation: </i>Transl Psychiatry <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42143058 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41398-026-04067-6 Languages: – Code: eng Text: English Titles: – TitleFull: Postoperative delirium in hip fracture patients linked to epigenetic alterations in inflammatory and immune pathways: a genome-wide DNA methylation study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Seki T – PersonEntity: Name: NameFull: Nishitani S – PersonEntity: Name: NameFull: Nishizawa Y – PersonEntity: Name: NameFull: Yamanishi K – PersonEntity: Name: NameFull: Shimura A – PersonEntity: Name: NameFull: Nishiguchi T – PersonEntity: Name: NameFull: Ishii T – PersonEntity: Name: NameFull: Aoyama B – PersonEntity: Name: NameFull: Santiago TA – PersonEntity: Name: NameFull: Phuong NJ – PersonEntity: Name: NameFull: Gorantla N – PersonEntity: Name: NameFull: Nguyen HD – PersonEntity: Name: NameFull: Takeda R – PersonEntity: Name: NameFull: Kameoka T – PersonEntity: Name: NameFull: Inoue T – PersonEntity: Name: NameFull: Sugiyama D – PersonEntity: Name: NameFull: Ueda K – PersonEntity: Name: NameFull: Yamanashi T – PersonEntity: Name: NameFull: Shinozaki G IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 05 Text: 2026 May 16 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2158-3188 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Translational psychiatry Type: main |
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