Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration.

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Bibliographic Details
Title: Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration.
Authors: Maddineni P; Department of Ophthalmology, School of Medicine, University of Missouri, 1 Hospital Dr, Columbia, MO, 65212, USA. pmbnv@health.missouri.edu., Kaipa BR; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, Irvine School of Medicine, University of California, 829 Health Sciences Rd, Irvine, CA, 92697, USA., Kodati B; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Kesavan K; Department of Ophthalmology, School of Medicine, University of Missouri, 1 Hospital Dr, Columbia, MO, 65212, USA., Li L; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Millar JC; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Yacoub S; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Kasetti RB; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Clark AF; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Zode GS; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, Irvine School of Medicine, University of California, 829 Health Sciences Rd, Irvine, CA, 92697, USA. gzode@hs.uci.edu.
Source: Molecular neurodegeneration [Mol Neurodegener] 2026 May 16; Vol. 21 (1). Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1750-1326
DOI:10.1186/s13024-026-00950-4