Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration.

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Title: Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration.
Authors: Maddineni P; Department of Ophthalmology, School of Medicine, University of Missouri, 1 Hospital Dr, Columbia, MO, 65212, USA. pmbnv@health.missouri.edu., Kaipa BR; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, Irvine School of Medicine, University of California, 829 Health Sciences Rd, Irvine, CA, 92697, USA., Kodati B; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Kesavan K; Department of Ophthalmology, School of Medicine, University of Missouri, 1 Hospital Dr, Columbia, MO, 65212, USA., Li L; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Millar JC; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Yacoub S; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Kasetti RB; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Clark AF; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA., Zode GS; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, Irvine School of Medicine, University of California, 829 Health Sciences Rd, Irvine, CA, 92697, USA. gzode@hs.uci.edu.
Source: Molecular neurodegeneration [Mol Neurodegener] 2026 May 16; Vol. 21 (1). Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration.
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  Data: <searchLink fieldCode="AU" term="%22Maddineni+P%22">Maddineni P</searchLink>; Department of Ophthalmology, School of Medicine, University of Missouri, 1 Hospital Dr, Columbia, MO, 65212, USA. pmbnv@health.missouri.edu.<br /><searchLink fieldCode="AU" term="%22Kaipa+BR%22">Kaipa BR</searchLink>; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, Irvine School of Medicine, University of California, 829 Health Sciences Rd, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Kodati+B%22">Kodati B</searchLink>; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA.<br /><searchLink fieldCode="AU" term="%22Kesavan+K%22">Kesavan K</searchLink>; Department of Ophthalmology, School of Medicine, University of Missouri, 1 Hospital Dr, Columbia, MO, 65212, USA.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA.<br /><searchLink fieldCode="AU" term="%22Millar+JC%22">Millar JC</searchLink>; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA.<br /><searchLink fieldCode="AU" term="%22Yacoub+S%22">Yacoub S</searchLink>; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA.<br /><searchLink fieldCode="AU" term="%22Kasetti+RB%22">Kasetti RB</searchLink>; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA.<br /><searchLink fieldCode="AU" term="%22Clark+AF%22">Clark AF</searchLink>; Department of Pharmacology and Neuroscience and North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, 76107, USA.<br /><searchLink fieldCode="AU" term="%22Zode+GS%22">Zode GS</searchLink>; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, Irvine School of Medicine, University of California, 829 Health Sciences Rd, Irvine, CA, 92697, USA. gzode@hs.uci.edu.
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  Data: <searchLink fieldCode="JN" term="%22101266600%22">Molecular neurodegeneration</searchLink> [Mol Neurodegener] 2026 May 16; Vol. 21 (1). <i>Date of Electronic Publication: </i>2026 May 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101266600 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1750-1326 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217501326%22">17501326 </searchLink><i>NLM ISO Abbreviation: </i>Mol Neurodegener <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13024-026-00950-4
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              Text: 2026 May 16
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