Do the children born after in vitro fertilization or intracytoplasmic sperm injection have poor intellectual performance? A prospective cohort study.

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Title: Do the children born after in vitro fertilization or intracytoplasmic sperm injection have poor intellectual performance? A prospective cohort study.
Authors: Jiang T; Children and Reproductive Health, State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China., Song Z; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China.; No. 971 Hospital of the People's Liberation Army Navy, Qingdao, Shandong, 266071, China., Xue X; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China., Li F; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China., Hu K; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China., Hu J; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China., Zhang Y; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China., Zhou W; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China. zzsmile12@163.com.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China. zzsmile12@163.com.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China. zzsmile12@163.com.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China. zzsmile12@163.com.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China. zzsmile12@163.com.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China. zzsmile12@163.com.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China. zzsmile12@163.com., Cui L; Children and Reproductive Health, State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China. fdclear3@126.com.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China. fdclear3@126.com.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China. fdclear3@126.com.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China. fdclear3@126.com.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China. fdclear3@126.com.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China. fdclear3@126.com.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China. fdclear3@126.com., Chen ZJ; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250012, China.; Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
Source: BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2026 May 18; Vol. 26 (1). Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967799 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2393 (Electronic) Linking ISSN: 14712393 NLM ISO Abbreviation: BMC Pregnancy Childbirth Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1471-2393
DOI:10.1186/s12884-026-09261-4