More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.

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Title: More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.
Authors: Joseph RE; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Britton RG; Division of Cancer Sciences, Cancer Research Centre, College of Life Sciences, University of Leicester, Leicester LE1 9HN, UK., Lin DY; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Roche J; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Purslow JA; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Fulton DB; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Fukasem P; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand., Gleeson MP; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand., Dyer MJS; The Ernest and Helen Scott Haematological Research Institute, Leicester Cancer Research Centre, College of Life Sciences, University of Leicester, Leicester LE1 9HN, UK., Wales TE; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA., Andreotti AH; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 08. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.05.07.723540