More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.

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Title: More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.
Authors: Joseph RE; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Britton RG; Division of Cancer Sciences, Cancer Research Centre, College of Life Sciences, University of Leicester, Leicester LE1 9HN, UK., Lin DY; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Roche J; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Purslow JA; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Fulton DB; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Fukasem P; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand., Gleeson MP; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand., Dyer MJS; The Ernest and Helen Scott Haematological Research Institute, Leicester Cancer Research Centre, College of Life Sciences, University of Leicester, Leicester LE1 9HN, UK., Wales TE; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA., Andreotti AH; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 08. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Joseph+RE%22">Joseph RE</searchLink>; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.<br /><searchLink fieldCode="AU" term="%22Britton+RG%22">Britton RG</searchLink>; Division of Cancer Sciences, Cancer Research Centre, College of Life Sciences, University of Leicester, Leicester LE1 9HN, UK.<br /><searchLink fieldCode="AU" term="%22Lin+DY%22">Lin DY</searchLink>; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.<br /><searchLink fieldCode="AU" term="%22Roche+J%22">Roche J</searchLink>; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.<br /><searchLink fieldCode="AU" term="%22Purslow+JA%22">Purslow JA</searchLink>; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.<br /><searchLink fieldCode="AU" term="%22Fulton+DB%22">Fulton DB</searchLink>; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.<br /><searchLink fieldCode="AU" term="%22Fukasem+P%22">Fukasem P</searchLink>; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Gleeson+MP%22">Gleeson MP</searchLink>; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Dyer+MJS%22">Dyer MJS</searchLink>; The Ernest and Helen Scott Haematological Research Institute, Leicester Cancer Research Centre, College of Life Sciences, University of Leicester, Leicester LE1 9HN, UK.<br /><searchLink fieldCode="AU" term="%22Wales+TE%22">Wales TE</searchLink>; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Andreotti+AH%22">Andreotti AH</searchLink>; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.
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        Value: 10.64898/2026.05.07.723540
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              Text: 2026 May 08
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