Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance.

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Title: Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance.
Authors: Ali MIH; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Akpinar ZF; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Ovando-Ricardez JA; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Casasent AK; Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lam TNA; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lin J; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khanmammadova N; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Reville PK; Department of Medicine, Division of Hematology/Oncology, Nuvance Health, Norwalk, CT., Shih DJH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Osunkoya AO; Departments of Pathology and Urology, Emory University School of Medicine, Atlanta, GA, USA., Norberg LM; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tran TM; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Li J; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hoang AG; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hanalioglu S; Department of Neurosurgery, Hacettepe University Faculty of Medicine, Ankara, Turkey., Bilen MA; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Lang F; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Huse JT; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Navin N; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hasanov M; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Jonasch E; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hasanov E; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 10. Date of Electronic Publication: 2026 May 10.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.05.06.722652