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Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance.

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Title: Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance.
Authors: Ali MIH; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Akpinar ZF; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Ovando-Ricardez JA; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Casasent AK; Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lam TNA; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lin J; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khanmammadova N; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Reville PK; Department of Medicine, Division of Hematology/Oncology, Nuvance Health, Norwalk, CT., Shih DJH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Osunkoya AO; Departments of Pathology and Urology, Emory University School of Medicine, Atlanta, GA, USA., Norberg LM; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tran TM; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Li J; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hoang AG; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hanalioglu S; Department of Neurosurgery, Hacettepe University Faculty of Medicine, Ankara, Turkey., Bilen MA; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Lang F; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Huse JT; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Navin N; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hasanov M; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Jonasch E; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hasanov E; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 10. Date of Electronic Publication: 2026 May 10.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance.
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  Data: <searchLink fieldCode="AU" term="%22Ali+MIH%22">Ali MIH</searchLink>; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Akpinar+ZF%22">Akpinar ZF</searchLink>; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ovando-Ricardez+JA%22">Ovando-Ricardez JA</searchLink>; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Casasent+AK%22">Casasent AK</searchLink>; Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lam+TNA%22">Lam TNA</searchLink>; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Khanmammadova+N%22">Khanmammadova N</searchLink>; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Reville+PK%22">Reville PK</searchLink>; Department of Medicine, Division of Hematology/Oncology, Nuvance Health, Norwalk, CT.<br /><searchLink fieldCode="AU" term="%22Shih+DJH%22">Shih DJH</searchLink>; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Osunkoya+AO%22">Osunkoya AO</searchLink>; Departments of Pathology and Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Norberg+LM%22">Norberg LM</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tran+TM%22">Tran TM</searchLink>; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hoang+AG%22">Hoang AG</searchLink>; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hanalioglu+S%22">Hanalioglu S</searchLink>; Department of Neurosurgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Bilen+MA%22">Bilen MA</searchLink>; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lang+F%22">Lang F</searchLink>; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Huse+JT%22">Huse JT</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Navin+N%22">Navin N</searchLink>; Department of Systems Biology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hasanov+M%22">Hasanov M</searchLink>; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Jonasch+E%22">Jonasch E</searchLink>; Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hasanov+E%22">Hasanov E</searchLink>; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
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