Structure-enabled enhancement of potency in a metronidazole-benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole.
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| Title: | Structure-enabled enhancement of potency in a metronidazole-benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole. |
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| Authors: | Velez ASMM; Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica, Brazil., Chaves OA; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Coimbra, Portugal.; Laboratory of Immunopharmacology, Center for Research, Innovation and Surveillance in COVID-19 and Health Emergencies (CPIV), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil., Costa T; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Coimbra, Portugal., Serpa C; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Coimbra, Portugal., Borges JM; Departamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil., Freire-de-Lima CG; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Decote-Ricardo D; Departamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil., Lima MEF; Department of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica, Brazil. |
| Source: | Frontiers in pharmacology [Front Pharmacol] 2026 Apr 30; Vol. 17, pp. 1812023. Date of Electronic Publication: 2026 Apr 30 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1663-9812 |
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| DOI: | 10.3389/fphar.2026.1812023 |
