An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity.

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Title: An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity.
Authors: Matuck BF; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA.; These authors contributed equally., Huynh KLA; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA.; These authors contributed equally., Pereira D; Center for Oral Immunobiology and Regenerative Medicine, Barts Centre for Squamous Cancer, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; These authors contributed equally., Easter QT; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA., Zhang X; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA., Kunz M; The Bioinformatics CRO, Sanford, FL, USA., Kumar N; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Pratapa A; Department of Cell Biology, Duke University, Durham, NC, USA., Rupp BT; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA., Ghodke A; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Predeus AV; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Fernandes A; Center for Oral Immunobiology and Regenerative Medicine, Barts Centre for Squamous Cancer, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Szabó L; Mildred-Scheel Early Career Centre (MSNZ) for Cancer Research, University Hospital Wuerzburg, Wuerzburg, Germany.; Department of Biochemistry and Molecular Biology, Biocenter, University of Wuerzburg, Wuerzburg, Germany., Hartmann S; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Würzburg, Germany., Harnischfeger N; Mildred-Scheel Early Career Centre (MSNZ) for Cancer Research, University Hospital Wuerzburg, Wuerzburg, Germany.; Department of Biochemistry and Molecular Biology, Biocenter, University of Wuerzburg, Wuerzburg, Germany., Khavandgar Z; Sjögren's Clinical Investigations Team, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA.; Salivary Disorders Unit, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA., Beach M; Sjögren's Clinical Investigations Team, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA.; Salivary Disorders Unit, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA., Perez P; Sjögren's Clinical Investigations Team, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA., Nilges B; OMAPiX, Inc, Leuven, Belgium., Moreno MM; OMAPiX, Inc, Leuven, Belgium., Ko KI; Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Singh R; Department of Cell Biology, Duke University, Durham, NC, USA., Tata PR; Department of Cell Biology, Duke University, Durham, NC, USA., Teichmann SA; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Kimple A; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Pringle S; University of Groningen and University Medical Center, Groningen, the Netherlands., Kretzschmar K; Mildred-Scheel Early Career Centre (MSNZ) for Cancer Research, University Hospital Wuerzburg, Wuerzburg, Germany.; Department of Biochemistry and Molecular Biology, Biocenter, University of Wuerzburg, Wuerzburg, Germany., Warner BM; Sjögren's Clinical Investigations Team, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA.; Salivary Disorders Unit, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA., Sequeira I; Center for Oral Immunobiology and Regenerative Medicine, Barts Centre for Squamous Cancer, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Senior author., Liu J; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA.; VCU Massey Comprehensive Cancer Center, Bioinformatics Shared Resource Core, Virginia Commonwealth University, Richmond, VA, USA.; Senior author., Byrd KM; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA.; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; VCU Massey Comprehensive Cancer Center, Bioinformatics Shared Resource Core, Virginia Commonwealth University, Richmond, VA, USA.; Senior author.; Lead contact.
Source: Cell press blue [Cell Press Blue] 2026 Apr 20; Vol. 1 (1).
Publication Type: Journal Article
Journal Info: Country of Publication: United States NLM ID: 9919258216806676 Publication Model: Print Cited Medium: Internet ISSN: 3051-3839 (Electronic) Linking ISSN: 30513839 NLM ISO Abbreviation: Cell Press Blue Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:3051-3839
DOI:10.1016/j.cpblue.2026.100007