Effect of inhaled interferon-β1a on SARS-CoV-2 diversity and evolution.

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Title: Effect of inhaled interferon-β1a on SARS-CoV-2 diversity and evolution.
Authors: Edelstein GE; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Sass TN; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Deo R; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Glover OT; Ragon Institute of Mass General Brigham, Cambridge, Massachusetts, USA., Boucau J; Ragon Institute of Mass General Brigham, Cambridge, Massachusetts, USA., Jaganathan P; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Chew KW; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA., Giganti MJ; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Hughes MD; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Moser C; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Javan AC; National Institutes of Health, Bethesda, Maryland, USA., Fletcher CV; College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA., McCarthy C; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Wohl DA; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Daar ES; Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA., Eron JJ; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Currier JS; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA., Singh U; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Smith DM; Department of Medicine, University of Carolina, San Diego, La Jolla, California, USA., Fischer W; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Barczak AK; Ragon Institute of Mass General Brigham, Cambridge, Massachusetts, USA., Choudhary MC; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Li JZ; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Corporate Authors: ACTIV-2/A5401 Study Team
Source: Microbiology spectrum [Microbiol Spectr] 2026 Jul 07; Vol. 14 (7), pp. e0054126. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Edelstein+GE%22">Edelstein GE</searchLink>; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sass+TN%22">Sass TN</searchLink>; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Deo+R%22">Deo R</searchLink>; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Glover+OT%22">Glover OT</searchLink>; Ragon Institute of Mass General Brigham, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Boucau+J%22">Boucau J</searchLink>; Ragon Institute of Mass General Brigham, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jaganathan+P%22">Jaganathan P</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Chew+KW%22">Chew KW</searchLink>; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Giganti+MJ%22">Giganti MJ</searchLink>; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hughes+MD%22">Hughes MD</searchLink>; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Moser+C%22">Moser C</searchLink>; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Javan+AC%22">Javan AC</searchLink>; National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Fletcher+CV%22">Fletcher CV</searchLink>; College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA.<br /><searchLink fieldCode="AU" term="%22McCarthy+C%22">McCarthy C</searchLink>; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Wohl+DA%22">Wohl DA</searchLink>; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Daar+ES%22">Daar ES</searchLink>; Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.<br /><searchLink fieldCode="AU" term="%22Eron+JJ%22">Eron JJ</searchLink>; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Currier+JS%22">Currier JS</searchLink>; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Singh+U%22">Singh U</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Smith+DM%22">Smith DM</searchLink>; Department of Medicine, University of Carolina, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Fischer+W%22">Fischer W</searchLink>; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Barczak+AK%22">Barczak AK</searchLink>; Ragon Institute of Mass General Brigham, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Choudhary+MC%22">Choudhary MC</searchLink>; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Li+JZ%22">Li JZ</searchLink>; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
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  Data: <searchLink fieldCode="JN" term="%22101634614%22">Microbiology spectrum</searchLink> [Microbiol Spectr] 2026 Jul 07; Vol. 14 (7), pp. e0054126. <i>Date of Electronic Publication: </i>2026 May 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ASM+Press%22">ASM Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101634614 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2165-0497 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221650497%22">21650497 </searchLink><i>NLM ISO Abbreviation: </i>Microbiol Spectr <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul 07
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