View in EDS

Safety and efficacy of astegolimab for COPD with frequent exacerbations regardless of baseline blood eosinophil counts (ALIENTO and ARNASA): randomised, double-blind, placebo-controlled, phase 2b and 3 trials.

Saved in:
Bibliographic Details
Title: Safety and efficacy of astegolimab for COPD with frequent exacerbations regardless of baseline blood eosinophil counts (ALIENTO and ARNASA): randomised, double-blind, placebo-controlled, phase 2b and 3 trials.
Authors: Papi A; Pulmonary Division, University of Ferrara, St Anna University Hospital, Ferrara, Italy. Electronic address: ppa@unife.it., Greening NJ; Institute for Lung Health, Department of Respiratory Sciences, University of Leicester, Leicester, UK., Bhatt SP; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Roche N; Université Paris Cité, APHP Centre, Hôpital et Institut Cochin, Paris, France., Celli B; Mass General Brigham Hospital, Harvard University Medical School, Boston, MA, USA., Wedzicha JA; National Heart and Lung Institute, Imperial College London, London, UK., Agustí À; University of Barcelona, Barcelona, Spain; Respiratory Institute, Hospital Clinic, Barcelona, Spain; FCRB-IDIBAPS, Barcelona, Spain; CIBER Enfermedades Respiratorias, ISCIII, Spain., Tal-Singer R; Global Allergy & Airways Patient Platform, Vienna, Austria., Han MK; University of Michigan, Ann Arbor, MI, USA., Janssens W; Department of Chronic Diseases and Metabolism (CHROMETA), University Hospital Leuven, KU Leuven, Belgium., Hanania NA; Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA., Nair P; Department of Medicine, McMaster University, Hamilton, ON, Canada; Research Institute of St Joe's Hamilton, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada., Bremner P; University of Notre Dame, Fremantle, WA, Australia., Porpodis K; Pulmonology Department, G Papanikolaou Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Shibata Y; Fukushima Medical University, Fukushima, Japan., Korn S; IKF Pneumologie Mainz, Mainz, Germany; Thoraxklinik Heidelberg, Heidelberg, Germany., Yang T; China-Japan Friendship Hospital, Beijing, China., Gordon O; Roche Products, Welwyn Garden City, Hertfordshire, UK., Saenz R; Genentech, South San Francisco, CA, USA., Ng J; Genentech, South San Francisco, CA, USA., Cheung DS; Genentech, South San Francisco, CA, USA., Devine J; Genentech, South San Francisco, CA, USA., Grimbaldeston MA; Genentech, South San Francisco, CA, USA., Zhang W; Genentech, South San Francisco, CA, USA., Yang X; Genentech, South San Francisco, CA, USA., Mohan D; Genentech, South San Francisco, CA, USA., Vogelmeier CF; Department of Medicine, Pulmonary, Critical Care and Sleep Medicine, Philipps University of Marburg, German Center for Lung Research (DZL), Marburg, Germany., Brightling CE; Institute for Lung Health, Department of Respiratory Sciences, University of Leicester, Leicester, UK.
Corporate Authors: ALIENTO and ARNASA investigators
Source: Lancet (London, England) [Lancet] 2026 May 23; Vol. 407 (10543), pp. 2027-2039. Date of Electronic Publication: 2026 May 18.
Publication Type: Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42150581
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Safety and efficacy of astegolimab for COPD with frequent exacerbations regardless of baseline blood eosinophil counts (ALIENTO and ARNASA): randomised, double-blind, placebo-controlled, phase 2b and 3 trials.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Papi+A%22">Papi A</searchLink>; Pulmonary Division, University of Ferrara, St Anna University Hospital, Ferrara, Italy. Electronic address: ppa@unife.it.<br /><searchLink fieldCode="AU" term="%22Greening+NJ%22">Greening NJ</searchLink>; Institute for Lung Health, Department of Respiratory Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Bhatt+SP%22">Bhatt SP</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Roche+N%22">Roche N</searchLink>; Université Paris Cité, APHP Centre, Hôpital et Institut Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Celli+B%22">Celli B</searchLink>; Mass General Brigham Hospital, Harvard University Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wedzicha+JA%22">Wedzicha JA</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Agustí+À%22">Agustí À</searchLink>; University of Barcelona, Barcelona, Spain; Respiratory Institute, Hospital Clinic, Barcelona, Spain; FCRB-IDIBAPS, Barcelona, Spain; CIBER Enfermedades Respiratorias, ISCIII, Spain.<br /><searchLink fieldCode="AU" term="%22Tal-Singer+R%22">Tal-Singer R</searchLink>; Global Allergy & Airways Patient Platform, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Han+MK%22">Han MK</searchLink>; University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Janssens+W%22">Janssens W</searchLink>; Department of Chronic Diseases and Metabolism (CHROMETA), University Hospital Leuven, KU Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Hanania+NA%22">Hanania NA</searchLink>; Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Nair+P%22">Nair P</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada; Research Institute of St Joe's Hamilton, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bremner+P%22">Bremner P</searchLink>; University of Notre Dame, Fremantle, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Porpodis+K%22">Porpodis K</searchLink>; Pulmonology Department, G Papanikolaou Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Shibata+Y%22">Shibata Y</searchLink>; Fukushima Medical University, Fukushima, Japan.<br /><searchLink fieldCode="AU" term="%22Korn+S%22">Korn S</searchLink>; IKF Pneumologie Mainz, Mainz, Germany; Thoraxklinik Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; China-Japan Friendship Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Gordon+O%22">Gordon O</searchLink>; Roche Products, Welwyn Garden City, Hertfordshire, UK.<br /><searchLink fieldCode="AU" term="%22Saenz+R%22">Saenz R</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ng+J%22">Ng J</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheung+DS%22">Cheung DS</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Devine+J%22">Devine J</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Grimbaldeston+MA%22">Grimbaldeston MA</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mohan+D%22">Mohan D</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vogelmeier+CF%22">Vogelmeier CF</searchLink>; Department of Medicine, Pulmonary, Critical Care and Sleep Medicine, Philipps University of Marburg, German Center for Lung Research (DZL), Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Brightling+CE%22">Brightling CE</searchLink>; Institute for Lung Health, Department of Respiratory Sciences, University of Leicester, Leicester, UK.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22ALIENTO+and+ARNASA+investigators%22">ALIENTO and ARNASA investigators</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2026 May 23; Vol. 407 (10543), pp. 2027-2039. <i>Date of Electronic Publication: </i>2026 May 18.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985213R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-547X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201406736%22">01406736 </searchLink><i>NLM ISO Abbreviation: </i>Lancet <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42150581
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S0140-6736(26)00637-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2027
    Titles:
      – TitleFull: Safety and efficacy of astegolimab for COPD with frequent exacerbations regardless of baseline blood eosinophil counts (ALIENTO and ARNASA): randomised, double-blind, placebo-controlled, phase 2b and 3 trials.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Papi A
      – PersonEntity:
          Name:
            NameFull: Greening NJ
      – PersonEntity:
          Name:
            NameFull: Bhatt SP
      – PersonEntity:
          Name:
            NameFull: Roche N
      – PersonEntity:
          Name:
            NameFull: Celli B
      – PersonEntity:
          Name:
            NameFull: Wedzicha JA
      – PersonEntity:
          Name:
            NameFull: Agustí À
      – PersonEntity:
          Name:
            NameFull: Tal-Singer R
      – PersonEntity:
          Name:
            NameFull: Han MK
      – PersonEntity:
          Name:
            NameFull: Janssens W
      – PersonEntity:
          Name:
            NameFull: Hanania NA
      – PersonEntity:
          Name:
            NameFull: Nair P
      – PersonEntity:
          Name:
            NameFull: Bremner P
      – PersonEntity:
          Name:
            NameFull: Porpodis K
      – PersonEntity:
          Name:
            NameFull: Shibata Y
      – PersonEntity:
          Name:
            NameFull: Korn S
      – PersonEntity:
          Name:
            NameFull: Yang T
      – PersonEntity:
          Name:
            NameFull: Gordon O
      – PersonEntity:
          Name:
            NameFull: Saenz R
      – PersonEntity:
          Name:
            NameFull: Ng J
      – PersonEntity:
          Name:
            NameFull: Cheung DS
      – PersonEntity:
          Name:
            NameFull: Devine J
      – PersonEntity:
          Name:
            NameFull: Grimbaldeston MA
      – PersonEntity:
          Name:
            NameFull: Zhang W
      – PersonEntity:
          Name:
            NameFull: Yang X
      – PersonEntity:
          Name:
            NameFull: Mohan D
      – PersonEntity:
          Name:
            NameFull: Vogelmeier CF
      – PersonEntity:
          Name:
            NameFull: Brightling CE
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 23
              M: 05
              Text: 2026 May 23
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1474-547X
          Numbering:
            – Type: volume
              Value: 407
            – Type: issue
              Value: 10543
          Titles:
            – TitleFull: Lancet (London, England)
              Type: main
ResultId 1