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De novo design of a macrocycle-induced dimerization system for cellular control.

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Title: De novo design of a macrocycle-induced dimerization system for cellular control.
Authors: Hanna S; Department of Chemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Salveson PJ; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Wicky B; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Kennedy MA; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Hicks DR; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Moller C; Institute for Protein Design, University of Washington, Seattle, WA, USA., Cheng S; Institute for Protein Design, University of Washington, Seattle, WA, USA., Li X; Institute for Protein Design, University of Washington, Seattle, WA, USA., Abedi M; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Coventry B; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Said MY; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Bera AK; Institute for Protein Design, University of Washington, Seattle, WA, USA., Kang A; Institute for Protein Design, University of Washington, Seattle, WA, USA., Stoddard BL; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Baker D; Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
Source: Nature communications [Nat Commun] 2026 May 18; Vol. 17 (1). Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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