Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states.
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| Title: | Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states. |
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| Authors: | Sanchez-Molina P; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Rosmus DD; Institute of Anatomy, Leipzig University, Leipzig, Germany.; Cellular Neuroanatomy, Chair of Anatomy and Cell Biology, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany.; Department of Neurology, Leipzig University Medical Center, Leipzig, Germany., Brownell D; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Meral M; ariadne.ai AG, Lucerne, Switzerland., Gohlich C; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Pratapa A; Akoya Biosciences, Marlborough, MA, USA., Peymanfar Y; Akoya Biosciences, Marlborough, MA, USA., Whitley A; Akoya Biosciences, Marlborough, MA, USA., Hou Y; Akoya Biosciences, Marlborough, MA, USA., Nikulina N; Akoya Biosciences, Marlborough, MA, USA., Bogachuk A; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Bouchard EL; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Chiot A; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA., Kuhrt H; Institute of Anatomy, Leipzig University, Leipzig, Germany., Wieghofer P; Institute of Anatomy, Leipzig University, Leipzig, Germany.; Cellular Neuroanatomy, Chair of Anatomy and Cell Biology, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany., Woltjer R; Department of Pathology, Oregon Health and Science University, Portland, OR, USA., Svara F; ariadne.ai AG, Lucerne, Switzerland., Braubach O; Akoya Biosciences, Marlborough, MA, USA. obraubach@icloud.com., Ajami B; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA. ajami@ohsu.edu.; Department of Behavioral and Systems Neuroscience, Oregon Health and Science University, Portland, OR, USA. ajami@ohsu.edu.; Department of Neurology and Regenerative Medicine Institute, Cedars Sinai, Los Angeles, CA, USA. ajami@ohsu.edu. |
| Source: | Nature neuroscience [Nat Neurosci] 2026 Jul; Vol. 29 (7), pp. 1599-1614. Date of Electronic Publication: 2026 May 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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