Metabolic Checkpoints in Cutaneous Squamous Cell Carcinoma: ACSL1 and PPARD Orchestrate Lipid-Ferroptosis Crosstalk via Keratinocyte Remodeling.

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Title: Metabolic Checkpoints in Cutaneous Squamous Cell Carcinoma: ACSL1 and PPARD Orchestrate Lipid-Ferroptosis Crosstalk via Keratinocyte Remodeling.
Authors: Shi XX; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Li GY; Department of Burns, Plastic, and Maxillofacial Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China., Yang XY; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Zeng ZX; Department of Burns, Plastic, and Maxillofacial Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China., Zhou TT; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Zhang YJ; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Huang MT; Department of Dermatology, The Affiliated Yan' an Hospital of Kunming Medical University, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, 650051, China., Tang Y; Department of Burns, Plastic, and Maxillofacial Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, China. drtangyang@126.com., Xu N; The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, 650100, China. xuning@kmmu.edu.cn.
Source: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2026 May 19. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1559-0291
DOI:10.1007/s12010-026-05734-6