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ERBB4 activation prevents microvascular dysfunction in a large animal model of hypertensive heart disease.

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Title: ERBB4 activation prevents microvascular dysfunction in a large animal model of hypertensive heart disease.
Authors: Tubeeckx MRL; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium., Bringmans T; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium., Goovaerts B; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium., Van den Bogaert S; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium., Grootaert MOJ; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Jones EAV; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Korpisalo P; Heart Center, Kuopio University Hospital, Kuopio, Finland., Juusola G; Heart Center, Kuopio University Hospital, Kuopio, Finland.; A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland., Wirth G; Heart Center, Kuopio University Hospital, Kuopio, Finland.; A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland., Murphy SL; Salubris Biotherapeutics, Inc., Gaithersburg, Maryland, United States., Heidbuchel H; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.; Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, Antwerp, Belgium., De Keulenaer GW; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.; Department of Cardiology, ZNA Middelheim, Antwerp, Belgium., Segers VFM; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.
Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2026 Jun 01; Vol. 330 (6), pp. H2025-H2035. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ERBB4 activation prevents microvascular dysfunction in a large animal model of hypertensive heart disease.
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  Data: <searchLink fieldCode="AU" term="%22Tubeeckx+MRL%22">Tubeeckx MRL</searchLink>; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Bringmans+T%22">Bringmans T</searchLink>; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Goovaerts+B%22">Goovaerts B</searchLink>; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+den+Bogaert+S%22">Van den Bogaert S</searchLink>; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Grootaert+MOJ%22">Grootaert MOJ</searchLink>; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Jones+EAV%22">Jones EAV</searchLink>; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Korpisalo+P%22">Korpisalo P</searchLink>; Heart Center, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Juusola+G%22">Juusola G</searchLink>; Heart Center, Kuopio University Hospital, Kuopio, Finland.; A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Wirth+G%22">Wirth G</searchLink>; Heart Center, Kuopio University Hospital, Kuopio, Finland.; A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Murphy+SL%22">Murphy SL</searchLink>; Salubris Biotherapeutics, Inc., Gaithersburg, Maryland, United States.<br /><searchLink fieldCode="AU" term="%22Heidbuchel+H%22">Heidbuchel H</searchLink>; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.; Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Keulenaer+GW%22">De Keulenaer GW</searchLink>; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.; Department of Cardiology, ZNA Middelheim, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Segers+VFM%22">Segers VFM</searchLink>; Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.
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  Data: <searchLink fieldCode="JN" term="%22100901228%22">American journal of physiology. Heart and circulatory physiology</searchLink> [Am J Physiol Heart Circ Physiol] 2026 Jun 01; Vol. 330 (6), pp. H2025-H2035. <i>Date of Electronic Publication: </i>2026 May 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901228 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1539 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203636135%22">03636135 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Heart Circ Physiol <i>Subsets: </i>MEDLINE
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        Value: 10.1152/ajpheart.00303.2025
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              Text: 2026 Jun 01
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