Tetrameric assembly disruption impairs CXCL4 chaperon ability for DNA and type I interferon immune amplification.

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Title: Tetrameric assembly disruption impairs CXCL4 chaperon ability for DNA and type I interferon immune amplification.
Authors: Ocone G; Istituto Superiore di Sanità, National center for Global Health, Roma, Italy., Mennella A; Istituto Superiore di Sanità, National center for Global Health, Roma, Italy., Pietraforte I; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy., Palazzo R; Istituto Superiore di Sanità, National center for Global Health, Roma, Italy., Spinelli FR; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Roma, Italy., Gaddini L; Istituto Superiore di Sanità, National Center for drug research and evaluation, Roma, Italy., Stefanantoni K; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Roma, Italy., Riccieri V; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Roma, Italy., Lee EY; Department of Bioengineering, Department of Chemistry & Biochemistry, and California, NanoSystems Institute, University of California, Los Angeles, CA, USA.; Department of Dermatology, University of California, San Francisco, CA, USA., Wong GCL; Department of Bioengineering, Department of Chemistry & Biochemistry, and California, NanoSystems Institute, University of California, Los Angeles, CA, USA., Lande R; Istituto Superiore di Sanità, National center for Global Health, Roma, Italy., Frasca L; Istituto Superiore di Sanità, National center for Global Health, Roma, Italy. loredana.frasca@iss.it.
Source: Communications biology [Commun Biol] 2026 May 19. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2399-3642
DOI:10.1038/s42003-026-10176-1