Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity.

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Title: Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity.
Authors: Freudenberg-Jahn K; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Ben-Horin I; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany., Murali Shankar N; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Schuldt M; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Ortiz-Montero P; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Loureiro LR; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany., Rackwitz W; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Opitz C; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Krutz L; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Breither T; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Oberoi P; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany., Häcker A; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany., Jäger D; Department of Medical Oncology, National Center for Tumor Diseases Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Kuhlmann JD; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Dresden and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany., Wimberger P; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Dresden and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany., Künzel SR; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Hölig K; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany., Feldmann A; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany., Bachmann M; Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.; National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.; Tumor Immunology, University Cancer Center (UCC), University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany., Wels WS; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany., Tonn T; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. t.tonn@blutspende.de.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany. t.tonn@blutspende.de.; German Red Cross Blood Donation Service Baden-Württemberg-Hessen gGmbH, Mannheim, Germany. t.tonn@blutspende.de.; Institute for Transfusion Medicine and Immunohematology, Clinics of the Goethe University, Frankfurt am Main, Germany. t.tonn@blutspende.de., Eitler J; Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. j.eitler@blutspende.de.; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany. j.eitler@blutspende.de.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany. j.eitler@blutspende.de.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 May 19; Vol. 45 (1). Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1756-9966
DOI:10.1186/s13046-026-03722-6