CRL4AMBRA1-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer.

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Title: CRL4AMBRA1-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer.
Authors: Sheng Y; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Ni T; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Ding X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Huang J; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Zhao X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Li X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Li Q; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Wang J; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Yang X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Zhang L; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Zheng X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Cao D; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Su R; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Lu X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Hou J; National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai, China., Wang Y; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.
Source: International journal of biological sciences [Int J Biol Sci] 2026 May 01; Vol. 22 (9), pp. 4976-4996. Date of Electronic Publication: 2026 May 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1449-2288
DOI:10.7150/ijbs.133072