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CRL4AMBRA1-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer.

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Title: CRL4AMBRA1-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer.
Authors: Sheng Y; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Ni T; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Ding X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Huang J; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Zhao X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Li X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Li Q; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Wang J; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Yang X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Zhang L; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Zheng X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Cao D; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Su R; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Lu X; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China., Hou J; National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai, China., Wang Y; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.
Source: International journal of biological sciences [Int J Biol Sci] 2026 May 01; Vol. 22 (9), pp. 4976-4996. Date of Electronic Publication: 2026 May 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
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  Data: CRL4<superscript>AMBRA1</superscript>-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer.
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  Data: <searchLink fieldCode="AU" term="%22Sheng+Y%22">Sheng Y</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ni+T%22">Ni T</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ding+X%22">Ding X</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zheng+X%22">Zheng X</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Cao+D%22">Cao D</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Su+R%22">Su R</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Hou+J%22">Hou J</searchLink>; National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.; Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, China.
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  Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2026 May 01; Vol. 22 (9), pp. 4976-4996. <i>Date of Electronic Publication: </i>2026 May 01 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International%22">Ivyspring International </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101235568 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1449-2288 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214492288%22">14492288 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Sci <i>Subsets: </i>MEDLINE
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        Value: 10.7150/ijbs.133072
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        Text: English
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        StartPage: 4976
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      – TitleFull: CRL4AMBRA1-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer.
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              Text: 2026 May 01
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