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Phase Separation Driven by Dynamic Interactions in the N-Terminal Intrinsically Disordered Region of the DEAD-Box RNA Helicase DDX3X.

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Title: Phase Separation Driven by Dynamic Interactions in the N-Terminal Intrinsically Disordered Region of the DEAD-Box RNA Helicase DDX3X.
Authors: Toyama Y; RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan., Inakami S; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan., Takarada M; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan., Okabe K; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan., Takeuchi K; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan.; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Science and Technology, 2-3-26 Aomi, Koto-ku, Tokyo 135-0063, Japan., Shimada I; RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.; Graduate School of Integrated Sciences for Life, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 Jun 03; Vol. 148 (21), pp. 21313-21331. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-5126
DOI:10.1021/jacs.5c22149