Cerebral arteries in mice with sickle cell disease are exposed to larger areas of low wall shear stress.

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Title: Cerebral arteries in mice with sickle cell disease are exposed to larger areas of low wall shear stress.
Authors: Montes AR; NIH Center for Biomedical Engineering Technology Acceleration, Bethesda, Maryland, United States.; Section on Mechanics and Tissue Remodeling Integrating Computational and Experimental Approaches, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States., Rivera CP; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States.; Department of Bioengineering, University of Texas at Dallas, Dallas, Texas, United States., Zhang SX; NIH Center for Biomedical Engineering Technology Acceleration, Bethesda, Maryland, United States.; Section on Mechanics and Tissue Remodeling Integrating Computational and Experimental Approaches, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States., Lee HS; NIH Center for Biomedical Engineering Technology Acceleration, Bethesda, Maryland, United States.; Section on Mechanics and Tissue Remodeling Integrating Computational and Experimental Approaches, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States., Huo Y; PKU-HKUST Shenzhen-Hong Kong Institution, Shenzhen, People's Republic of China.; Institute of Mechanobiology and Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China., Platt MO; NIH Center for Biomedical Engineering Technology Acceleration, Bethesda, Maryland, United States.; Section on Mechanics and Tissue Remodeling Integrating Computational and Experimental Approaches, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States.
Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2026 Jul 01; Vol. 331 (1), pp. H23-H34. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1522-1539
DOI:10.1152/ajpheart.00056.2026