Reproductive toxicity induced by a repeated 28-day oral exposure to a commercial mixture of the herbicides S-metolachlor and flumioxazin in male rats.

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Title: Reproductive toxicity induced by a repeated 28-day oral exposure to a commercial mixture of the herbicides S-metolachlor and flumioxazin in male rats.
Authors: Carvalho RK; Laboratory of Physiology and Pharmacology of Reproduction, Department of Pharmacology, Federal University of Goiás, Goiânia, GO, Brazil., Reis DS; Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products, State University of Goiás, Anápolis, GO, Brazil., Santiago ALG; Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products, State University of Goiás, Anápolis, GO, Brazil., Rodrigues BM; Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products, State University of Goiás, Anápolis, GO, Brazil., Leite JA; Institute of Biological Sciences, Department of Pharmacology, Federal University of Goiás, Goiânia, GO, Brazil., Júnior WD; Laboratory of Physiology and Toxicological Biochemistry, State University of Goiás, Ceres, GO, Brazil., Damin V; School of Agronomy, Federal University of Goiás, Goiânia, GO, Brazil., Andersen ML; Department of Psychobiology, Federal University of São Paulo, São Paulo, SP, Brazil., Souza MR; Department of Psychobiology, Federal University of São Paulo, São Paulo, SP, Brazil., Ghedini PC; Laboratory of Molecular and Biochemistry Pharmacology, Department of Pharmacology, Federal University of Goiás, Goiânia, GO, Brazil., Campos HM; Laboratory of Molecular and Biochemistry Pharmacology, Department of Pharmacology, Federal University of Goiás, Goiânia, GO, Brazil., Silva DM; Laboratory of Mutagenesis, Department of Genetics, Federal University of Goiás, Goiânia, GO, Brazil., Amaral VCS; Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products, State University of Goiás, Anápolis, GO, Brazil., Almeida LM; Laboratory of Biotechnology, State University of Goiás, Anápolis, GO, Brazil., Mazaro-Costa R; Laboratory of Physiology and Pharmacology of Reproduction, Department of Pharmacology, Federal University of Goiás, Goiânia, GO, Brazil. Electronic address: mazaro@ufg.br.
Source: Chemico-biological interactions [Chem Biol Interact] 2026 Jul 25; Vol. 435, pp. 112151. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1872-7786
DOI:10.1016/j.cbi.2026.112151