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Inhibition of the mitochondrial pyruvate carrier attenuates the integrated stress response activation in a cellular model of Huntington's disease.

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Title: Inhibition of the mitochondrial pyruvate carrier attenuates the integrated stress response activation in a cellular model of Huntington's disease.
Authors: Oliveira Â; UCIBIO Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, Universidade do Porto, 4500-313, Porto, Portugal.; Associate Laboratory i4HB Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, 4500-313, Porto, Portugal., Almeida LM; UCIBIO Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, Universidade do Porto, 4500-313, Porto, Portugal.; Associate Laboratory i4HB Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, 4500-313, Porto, Portugal., Oliveira JMA; UCIBIO Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, Universidade do Porto, 4500-313, Porto, Portugal. jorgemao@ff.up.pt.; Associate Laboratory i4HB Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, 4500-313, Porto, Portugal. jorgemao@ff.up.pt., Pinho BR; UCIBIO Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, Universidade do Porto, 4500-313, Porto, Portugal. brpinho@ff.up.pt.; Associate Laboratory i4HB Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, 4500-313, Porto, Portugal. brpinho@ff.up.pt.
Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2026 Jul; Vol. 481 (7), pp. 2881-2894. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-4919
DOI:10.1007/s11010-026-05573-3