Hypoactivity, abnormal development of dendrites relevant to impaired synaptic transmission of calretinin-expressing interneurons in the medial prefrontal cortex underlies social deficits of mouse model in autism.

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Title: Hypoactivity, abnormal development of dendrites relevant to impaired synaptic transmission of calretinin-expressing interneurons in the medial prefrontal cortex underlies social deficits of mouse model in autism.
Authors: Chen M; Henan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, 450018, China., Zhao K; Henan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, 450018, China., Gao C; Department of Rehabilitation, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China., Mei D; Department of Neurology, Children's Hospital of Soochow University, Suzhou, China., Shi S; Department of Image, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China., Wang L; Department of Neurology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China., Sun L; Shanghai Institute of Microsystem and Information Technology, Shanghai, China., Guo J; Department of Pathology, School of Basic Medical Sciences, Yantai Campus of Binzhou Medical University, Yantai, China., Bin G; School of traditional Chinese medicine, Ningxia Medical University, Xingqing, Ningxia, China., Zhao S; Henan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, 450018, China., Yan X; Henan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, 450018, China., He M; Institutes of Brain Science, State Key laboratory of medical neurobiology and MOE Frontiers center for Brain Science, department of neurobiology, Zhongshan hospital, Fudan University, Shanghai, China. hem@fudan.edu.cn., Zhang Y; Henan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, 450018, China. syek@163.com., Wang X; Henan Key Laboratory of Genetic and Developmental Disorders, Henan Children's Neurodevelopment Engineering Research Center, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, 450018, China. xiaonawang2015@163.com.
Source: Translational psychiatry [Transl Psychiatry] 2026 May 21; Vol. 16 (1). Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-026-04123-1