Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial.

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Title: Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial.
Authors: Lee RJ; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Rebecca.lee-3@manchester.ac.uk.; The Christie NHS Foundation Trust, Manchester, UK. Rebecca.lee-3@manchester.ac.uk., Rothwell DG; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Smith N; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Chow S; Department of Medical Oncology, Clatterbridge Cancer Centre, Liverpool, UK., Delgado-SanMartin J; NHLI Data Science, Imperial College London, London, UK.; Systems Forecasting, Manchester, UK., Mistry H; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Systems Forecasting, Manchester, UK., Sylvestre Y; Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Chiang SC; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Clarke H; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Gremel G; Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK., Gupta A; The Christie NHS Foundation Trust, Manchester, UK., Hockenhull K; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Kelso N; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Kochhar R; The Christie NHS Foundation Trust, Manchester, UK., Mullan D; The Christie NHS Foundation Trust, Manchester, UK., Plummer R; Sir Bobby Robson Cancer Trials Research Centre, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, UK.; Newcastle University, Newcastle upon Tyne, UK., Serra P; The Christie NHS Foundation Trust, Manchester, UK., Shaw H; Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK., Summersgill H; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Turajlic S; Skin and Renal Units, The Royal Marsden NHS Foundation Trust, London, UK.; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK., Mouliere F; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Marais R; Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK.; Oncodrug Ltd, Macclesfield, UK., Dive C; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Lorigan P; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. paul.lorigan@nhs.net.; The Christie NHS Foundation Trust, Manchester, UK. paul.lorigan@nhs.net.
Source: Nature communications [Nat Commun] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72735-8